How Do You Spell HEREDITARY MUSCULAR ATROPHY OF PERONEAL TYPE?

Pronunciation: [hɪɹˈɛdɪtəɹi mˈʌskjʊləɹ ˈatɹəfi ɒv pˈɛɹə͡ʊnə͡l tˈa͡ɪp] (IPA)

Hereditary Muscular Atrophy of Peroneal Type is a medical term that refers to a group of inherited disorders that affect peripheral nerves responsible for controlling movement. Its spelling can be explained through the International Phonetic Alphabet (IPA) as /hɛrɪˈdɪtəri ˈmʌskjʊlər ˈætrəfi əv pəˈroʊniəl taɪp/. The phonetic symbols represent the exact pronunciation for each letter and sound in the word. Understanding the IPA can help healthcare professionals accurately communicate medical terminology and improve patient care.

HEREDITARY MUSCULAR ATROPHY OF PERONEAL TYPE Meaning and Definition

  1. Hereditary muscular atrophy of peroneal type, also known as Charcot-Marie-Tooth disease type 4 (CMT4), is a genetic disorder that affects the peripheral nerves, leading to muscle weakness and wasting, primarily in the lower legs and feet. It is classified as a peripheral neuropathy, which implies damage to the peripheral nerves that extend from the spinal cord to the muscles.

    This condition is inherited in an autosomal recessive manner, meaning that an affected individual must inherit two copies of the defective gene, one from each parent, to develop the disease. The specific genetic mutations associated with CMT4 affect proteins involved in the structure and function of peripheral nerves.

    The main symptoms include progressive muscle weakness and wasting, particularly in the muscles surrounding the shinbone (peroneal muscles). This can lead to foot drop, weakness in ankle muscles, and a high-stepped or "slapping" gait. Sensory abnormalities such as numbness, tingling, and decreased sensation in the feet and lower legs may also be present.

    Diagnosis of hereditary muscular atrophy of peroneal type often involves a thorough clinical evaluation, nerve conduction studies, electromyography, and genetic testing to confirm the presence of specific genetic mutations. Currently, there is no cure for CMT4, and treatment mainly focuses on managing symptoms and maintaining functionality through physical therapy, orthopedic interventions (braces or splints), and pain management.

    Overall, hereditary muscular atrophy of peroneal type is a genetic disorder characterized by progressive muscle weakness and wasting primarily in the lower legs and feet, caused by specific genetic mutations affecting peripheral nerves.

  2. Charcot-Marie type, a familial muscular atrophy affecting primarily the anterior muscles of the legs, and later sometimes the muscles of the forearms and hands.

    A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.

Common Misspellings for HEREDITARY MUSCULAR ATROPHY OF PERONEAL TYPE

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