CENPA Meaning and
Definition
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CENPA, also known as Centromere Protein A, is a crucial protein involved in the assembly and maintenance of centromeres. Centromeres are specific regions on chromosomes that play a vital role in cell division and genome stability. They are responsible for attaching duplicated chromosomes to the spindle fibers during cell division.
CENPA is a specialized histone protein that is found at the centromeric region of chromosomes. Histones help in packaging and organizing DNA within the nucleus of cells. CENPA, being a key component of centromeric chromatin, plays a pivotal role in ensuring proper chromosome segregation during mitosis.
The presence of CENPA at the centromere helps in recruiting other centromeric proteins and chromatin modifiers, forming a functional centromere. It is involved in the establishment of the kinetochore, which is a protein complex that connects centromeres to spindle fibers and aids in chromosome movement during cell division.
Abnormalities or deficiencies in CENPA can lead to chromosome missegregation and aneuploidy, a condition where cells have an abnormal number of chromosomes. This can have severe consequences, including genetic disorders and development of cancerous cells.
Research on CENPA is crucial for understanding the fundamental mechanisms behind chromosome segregation and the maintenance of genome stability. It also has implications in cancer research, as targeting CENPA or other centromeric proteins may provide potential avenues for novel cancer therapies.
Common Misspellings for CENPA
- cenpla
- cen0pa
- cenpza
- cenpaz
- cenpsa
- cenpwa
- cenpaw
- cenpqa
- cenpaq
- ecnpa
- cepna
- ccenpa
- ceenpa
- cennpa
- kENPA
- bENPA
- CgNPA
- CENxA
- c enpa
- ce npa
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