ALCIAN BLUE GS Meaning and
Definition
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Alcian Blue GS is a synthetic dye that is widely used in histology and histopathology as a selective histochemical stain. With a chemical formula of C56H72ClN9O14S·Pd, it belongs to the family of phthalocyanine dyes and is also referred to by other names such as Alcian Blue 8GX and Alcian Blue FFR.
This dye has a deep blue color and a high affinity for acidic mucopolysaccharides, particularly those that contain sulfate or carboxyl groups. It is commonly utilized to stain glycosaminoglycans (GAGs) and sulfated proteoglycans in various tissues and cell cultures. When used in conjunction with other stains, such as hematoxylin or eosin, Alcian Blue GS can help differentiate and highlight different components within biological samples.
The staining process involves the incubation of the specimen in a solution containing Alcian Blue GS and appropriate chemical fixatives. Acidic mucopolysaccharides present in the tissue or cell matrix specifically bind to the dye molecule, resulting in a visible blue coloration. The intensity of the staining can be adjusted by altering the concentration, pH, or duration of the staining process.
Alcian Blue GS has proven to be a valuable tool in research and diagnostic laboratories, facilitating the identification and characterization of various tissues and structures within biological specimens. Its specificity for acidic mucopolysaccharides makes it particularly useful in the study of cartilage, mucin-secreting cells, and other extracellular matrix components.
Common Misspellings for ALCIAN BLUE GS
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