BRAF Meaning and
Definition
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BRAF, an acronym for "v-Raf murine sarcoma viral oncogene homolog B", refers to a specific gene that encodes a protein kinase enzyme known as B-Raf. It is a crucial component of an intracellular signaling pathway called the mitogen-activated protein kinase (MAPK) pathway. This pathway is involved in regulating cell proliferation, differentiation, and survival.
In the field of medicine, BRAF has gained significant attention due to its role in various diseases, particularly cancer. Mutations in the BRAF gene can lead to abnormal activation of the B-Raf protein kinase, resulting in dysregulated cell signaling and increased cell growth. Such mutations are commonly found in certain types of cancers, including malignant melanoma, colorectal cancer, thyroid cancer, and lung cancer.
The abnormal activation of the B-Raf protein kinase caused by mutations in the BRAF gene has led to the development of targeted therapies in cancer treatment. Inhibitors of BRAF, known as BRAF inhibitors, have been developed to specifically target and inhibit the abnormal activity of the mutated B-Raf protein. These inhibitors have shown promising results in improving patient outcomes, providing a more targeted and effective approach in treating certain types of cancer.
Given its critical role in cellular signaling and its implications in cancer, the study of BRAF and its associated mutations continues to be an active area of research in the field of molecular biology and medicine.
Common Misspellings for BRAF
- vbraf
- hbraf
- brfaf
- b5raf
- br5af
- b4raf
- br4af
- brzaf
- brazf
- brsaf
- brwaf
- brqaf
- braqf
- bravf
- brafv
- brafr
- brraf
- b raf
- br af
- bra f
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