Pronunciation: [bɹuːɡˈɑːdə sˈɪndɹə͡ʊm] (IPA) 
Correct spelling for the English word "brugada syndrome" is [bɹuːɡˈɑːdə sˈɪndɹə͡ʊm], [bɹuːɡˈɑːdə sˈɪndɹəʊm], [b_ɹ_uː_ɡ_ˈɑː_d_ə s_ˈɪ_n_d_ɹ_əʊ_m] (IPA phonetic alphabet).
Brugada syndrome is a cardiac disorder characterized by abnormal electrical activity in the heart, leading to potentially life-threatening arrhythmias. This genetic condition primarily affects the functioning of sodium channels in the cells responsible for regulating the heartbeat.
Individuals with Brugada syndrome may experience episodes of rapid heartbeat (tachycardia) or irregular heart rhythms, such as ventricular fibrillation. These irregular rhythms can be triggered by certain factors, including fever, certain medications, or electrolyte imbalances. Symptoms of the syndrome can vary widely, with some individuals remaining asymptomatic, while others may exhibit fainting (syncope), seizures, or even sudden cardiac arrest.
Diagnosis of Brugada syndrome involves a combination of symptoms, electrocardiogram (ECG) findings, and genetic testing. ECG typically reveals a characteristic pattern known as the Brugada sign, which consists of specific abnormalities in the electrical waveform. Genetic testing can identify mutations in certain genes associated with the syndrome, confirming the diagnosis in some cases.
Treatment for Brugada syndrome aims to prevent the occurrence of life-threatening arrhythmias and includes the use of implantable cardioverter-defibrillators (ICDs), which can deliver an electric shock to restore the normal heartbeat in case of an episode. Additionally, individuals diagnosed with Brugada syndrome are advised to avoid certain triggers, such as specific medications or excessive alcohol consumption.
Overall, Brugada syndrome is a rare cardiac disorder that requires medical attention and monitoring to prevent potentially fatal arrhythmias.
The term "Brugada syndrome" is named after the Spanish cardiologists Pedro and Josep Brugada, who together described the syndrome in a scientific publication in 1992. It is a hereditary heart disorder characterized by a specific electrocardiographic (ECG) pattern and an increased risk of sudden cardiac death. The syndrome was named after the Brugada brothers due to their significant contributions to its recognition and understanding.
