The c abl Proto Oncogene is a cellular gene that plays a crucial role in regulating cell growth and division. It belongs to the family of proto-oncogenes, which are genes that can potentially transform into oncogenes and promote the development of cancer.
The c abl Proto Oncogene encodes a protein called Abelson tyrosine kinase (c-Abl), which is involved in various cellular processes like cell cycle progression, DNA repair, and apoptosis. The protein acts as a kinase, meaning it adds phosphate groups to other proteins, thereby modifying their functions.
Under normal circumstances, the c-Abl protein is tightly regulated and its activity is carefully controlled to ensure proper cell functioning. However, if there are alterations in the gene or changes in the regulatory mechanisms, the c abl Proto Oncogene can become an oncogene and promote uncontrolled cell division and tumor formation.
Mutations or aberrations in the c abl Proto Oncogene have been identified in certain types of cancers, particularly in chronic myeloid leukemia (CML) and some cases of acute lymphoblastic leukemia (ALL). These mutations can result in the overactivity of the c-Abl protein, leading to the unregulated growth of cancer cells.
Understanding the functions and dysregulations of the c abl Proto Oncogene is important in the development of targeted therapies for cancer treatment. Drugs known as tyrosine kinase inhibitors have been developed to specifically suppress the activity of the c-Abl protein, offering effective treatment options for patients with certain types of leukemia.
