How Do You Spell CASTLEMAN DISEASE?

Pronunciation: [kˈasə͡lmən dɪzˈiːz] (IPA)

Castleman Disease, also known as Castleman's Disease or giant lymph node hyperplasia, is a rare disorder that affects the lymph nodes and related tissues. The word "Castleman" is spelled with three syllables and pronounced as /ˈkæsəlmən/. The "c" in "Castleman" is pronounced as /k/ and the "a" in the second syllable is pronounced as /ə/. The word is named after Dr. Benjamin Castleman, who first described the disease in 1954. Castleman Disease can present in different forms, ranging from mild and localized to severe and systemic.

CASTLEMAN DISEASE Meaning and Definition

1. Castleman disease is a rare and poorly understood disorder characterized by the abnormal growth of lymph nodes. It is also known as Castleman syndrome, giant lymph node hyperplasia, or angiofollicular lymph node hyperplasia. This condition affects the lymphatic system, which is a part of the immune system responsible for producing and transporting lymphocytes, a type of white blood cell that helps fight infection.

   Castleman disease typically presents as an enlargement of lymph nodes, particularly in the chest, abdomen, neck, or groin. It can occur in two forms: unicentric Castleman disease (UCD), which affects only one lymph node or a group of adjacent nodes, and multicentric Castleman disease (MCD), which affects multiple lymph nodes throughout the body. MCD can be more severe and is often associated with systemic symptoms such as fever, weight loss, night sweats, fatigue, and generalized lymphadenopathy.

   The exact cause of Castleman disease is unclear, but it is believed to involve an abnormal immune response. Certain viral infections, such as the human herpesvirus 8 (HHV-8), have been found to be associated with MCD. The disease can be diagnosed through physical examination, lymph node biopsy, imaging tests, and blood tests.

   Treatment for Castleman disease depends on the subtype and severity of the condition. Unicentric Castleman disease can often be cured with surgery, while multicentric Castleman disease requires a broader approach that may include drugs targeting the immune response, chemotherapy, immunotherapy, or radiation therapy. Ongoing research is focused on better understanding the disease and developing more effective treatments.

Common Misspellings for CASTLEMAN DISEASE

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Etymology of CASTLEMAN DISEASE

The term "Castleman disease" is named after Dr. Benjamin Castleman, an American pathologist who first described the condition in 1954. While studying unusual lymph node disorders, Dr. Castleman identified a group of individuals with a distinct type of lymph node hyperplasia, characterized by the enlargement of lymph nodes and abnormal growth patterns. His observations and subsequent publication led to the recognition of this condition as a unique disease, which was later named after him.