How Do You Spell CLONAL DELETION?

Pronunciation: [klˈə͡ʊnə͡l dɪlˈiːʃən] (IPA)

Clonal deletion is a process in immunology where immune cells that could potentially cause harm to the body are eliminated. The word is spelled /ˈkloʊnəl dɪˈlɛʃən/, with two syllables in "clonal" and three in "deletion". The IPA phonetic transcription helps to accurately convey the pronunciation of this technical term. Understanding the proper spelling and pronunciation of this word is essential for those in the field of immunology and medical research.

CLONAL DELETION Meaning and Definition

1. Clonal deletion is a process that occurs during the development of the immune system, specifically in the maturation of immune cells known as lymphocytes. it refers to the elimination or deletion of specific lymphocytes that recognize or react against self-antigens.

   This process plays a crucial role in maintaining self-tolerance and preventing autoimmunity, as lymphocytes that recognize self-antigens are eliminated or rendered non-functional. Clonal deletion primarily occurs in the thymus for T-cells and in the bone marrow for B-cells.

   The mechanism of clonal deletion involves the identification of self-reactive lymphocytes through the presentation of self-antigens by specialized cells known as antigen-presenting cells. If a lymphocyte recognizes self-antigens with high affinity, it is induced to undergo apoptosis, or programmed cell death. This prevents the development of mature lymphocytes that could potentially target and damage healthy tissues.

   Clonal deletion is a critical process for establishing a functional immune system that can recognize and respond to foreign antigens while maintaining tolerance to self-antigens. Defects in clonal deletion can lead to the escape of self-reactive lymphocytes, resulting in autoimmune diseases where the immune system mistakenly attacks the body's own cells and tissues.

   Overall, clonal deletion is an essential component of immune system development that ensures the balance between immune protection and self-tolerance.

Common Misspellings for CLONAL DELETION

• xlonal deletion
• vlonal deletion
• flonal deletion
• dlonal deletion
• ckonal deletion
• cponal deletion
• coonal deletion
• clinal deletion
• clknal deletion
• cllnal deletion
• clpnal deletion
• cl0nal deletion
• cl9nal deletion
• clobal deletion
• clomal deletion
• clojal deletion
• clohal deletion
• clonzl deletion
• clonsl deletion
• clonwl deletion

Etymology of CLONAL DELETION

The word "clonal deletion" comes from the combination of two terms: "clone" and "deletion".

"Clone" is derived from the Greek word "klōn", meaning "twig" or "branch". It refers to a group of genetically identical cells that are derived from a single ancestor cell through asexual reproduction or cell division.

"Deletion" comes from the Latin word "deletionem", derived from "deletus", which means "to destroy", "to blot out", or "to erase". It refers to the removal or elimination of something.

In the context of immunology, "clonal deletion" refers to the process of eliminating self-reactive immune cells (specifically, T and B lymphocytes) during their development, so they do not attack the body's own tissues. This process plays a crucial role in maintaining self-tolerance and preventing autoimmune diseases.

Plural form of CLONAL DELETION is CLONAL DELETIONS