How Do You Spell DEADENYLATION?

Pronunciation: [dˌɛdənɪlˈe͡ɪʃən] (IPA)

Deadenylation is spelled as /ˌdɛdənəˈleɪʃən/, which follows the English language's phonetic rules. The "d" sound at the beginning is followed by the "e" sound, pronounced as "eh" (/ɛ/). The next syllable features the "de" sound, pronounced as "deh" (/de/). It is followed by a short "n" sound (/n/), then a long "a" (/eɪ/) and the "sh" sound (/ʃ/) at the end. This term refers to the enzymatic process of removing the poly(A) tail from messenger RNA molecules.

DEADENYLATION Meaning and Definition

1. Deadenylation is a biological process that occurs in cells, specifically in the regulation of messenger RNA (mRNA) molecules. It refers to the removal or shortening of the poly(A) tail at the 3' end of an mRNA molecule. The poly(A) tail is a chain of adenosine nucleotides that is added to the mRNA during transcription, and its length is an important factor in mRNA stability, localization, and translation.

   The deadenylation process is crucial in regulating mRNA turnover and gene expression. It can be initiated by specific deadenylases, enzymes that recognize and cleave the poly(A) tail. Once the poly(A) tail is shortened or completely removed, the mRNA becomes susceptible to degradation by exonucleases, leading to its rapid decay.

   Deadenylation plays a vital role in gene expression control as it affects the stability of mRNAs and their subsequent translation into proteins. It is involved in various cellular processes such as mRNA quality control, mRNA decay, and the regulation of cellular response to environmental stimuli.

   Defects in deadenylation can result in abnormal gene expression and have been associated with certain diseases and developmental disorders. Studying deadenylation and the enzymes involved in this process can provide insights into cellular regulatory mechanisms and potentially lead to the development of therapeutic strategies targeting mRNA stability and gene expression.

Common Misspellings for DEADENYLATION

• seadenylation
• xeadenylation
• ceadenylation
• feadenylation
• readenylation
• eeadenylation
• dwadenylation
• dsadenylation
• ddadenylation
• dradenylation
• d4adenylation
• d3adenylation
• dezdenylation
• desdenylation
• dewdenylation
• deqdenylation
• deasenylation
• deaxenylation
• deacenylation
• deafenylation

Etymology of DEADENYLATION

The word "deadenylation" is formed by combining the prefix "de-" meaning "remove" or "reverse" and the base "adenylation".

The base "adenylation" is derived from the term "adenylate", which refers to the ester or salt of adenylic acid. Adenylic acid, in turn, is derived from the nucleotide adenosine triphosphate (ATP).

Therefore, "deadenylation" can be interpreted as the process of removing or reversing adenylic acid or its derivatives. In biology, it specifically refers to the enzymatic removal of the adenylate residue from the 3' end of an RNA molecule.