How Do You Spell DEBRISOQUINE HYDROXYLASE?

Pronunciation: [dˈɛbɹɪsˌɒkwa͡ɪn hˈa͡ɪdɹəksˌɪle͡ɪs] (IPA)

The spelling of the term "Debrisoquine Hydroxylase" can seem complicated at first glance, but it can be broken down using IPA phonetic transcription. The word is pronounced as dɛbrɪsoʊkwɪn haɪˈdrɒksɪleɪz. The "s" sound is used rather than "z" in the suffix "ose," and "u" is pronounced as "ʊ." The silent "e" at the end of "debrisoquine" also affects the pronunciation of the preceding "i." Understanding the IPA phonetic transcription can help clarify the spelling and pronunciation of complex scientific terms like this.

DEBRISOQUINE HYDROXYLASE Meaning and Definition

1. Debrisoquine hydroxylase, also known as cytochrome P450 2D6 (CYP2D6), is an enzyme involved in the metabolism of various drugs in the body. It is primarily responsible for the oxidation and hydroxylation of debrisoquine, a drug used primarily as an antihypertensive agent.

   Debrisoquine hydroxylase is a member of the cytochrome P450 superfamily of enzymes, which are involved in the metabolism of numerous substances including drugs, toxins, and endogenous compounds. This enzyme is mainly found in the liver, although it is also expressed in other tissues such as the brain and intestines.

   The activity of debrisoquine hydroxylase can vary greatly among individuals due to genetic polymorphisms. Some individuals may have a gene variant that results in decreased or absent enzyme activity, known as poor metabolizers. On the other hand, extensive metabolizers have normal enzyme activity. These genetic differences can have significant clinical implications, as the metabolism of various drugs that are substrates for debrisoquine hydroxylase may be altered in individuals with different enzyme activity levels.

   The measurement of debrisoquine hydroxylase activity is often used as a marker for the assessment of drug metabolism capacity in clinical settings. This information can help guide personalized drug therapy, as individuals may require dose adjustments based on their enzyme activity level. Additionally, knowledge of an individual’s debrisoquine hydroxylase phenotype is important in predicting drug-drug interactions, adverse drug reactions, and therapeutic efficacy.

Common Misspellings for DEBRISOQUINE HYDROXYLASE

• sebrisoquine hydroxylase
• xebrisoquine hydroxylase
• cebrisoquine hydroxylase
• febrisoquine hydroxylase
• rebrisoquine hydroxylase
• eebrisoquine hydroxylase
• dwbrisoquine hydroxylase
• dsbrisoquine hydroxylase
• ddbrisoquine hydroxylase
• drbrisoquine hydroxylase
• d4brisoquine hydroxylase
• d3brisoquine hydroxylase
• devrisoquine hydroxylase
• denrisoquine hydroxylase
• dehrisoquine hydroxylase
• degrisoquine hydroxylase
• debeisoquine hydroxylase
• debdisoquine hydroxylase
• debfisoquine hydroxylase
• debtisoquine hydroxylase

Etymology of DEBRISOQUINE HYDROXYLASE

The word "Debrisoquine Hydroxylase" is a specific term used in the field of pharmacology to describe an enzyme responsible for the metabolism of debrisoquine, a drug used to treat hypertension.

The etymology of the term can be broken down as follows:

1. Debrisoquine: The term "debrisoquine" is a compound word derived from its chemical structure. The prefix "de" indicates the removal or absence of something, while "bri" and "soquin" likely do not have specific etymological meanings. The suffix "-ine" is commonly used in the chemical nomenclature of drugs to indicate that it is an alkaloid compound.

2. Hydroxylase: The term "hydroxylase" is a combining form derived from the Greek word "hydor" meaning "water" and the suffix "-yl" indicating a hydrocarbon radical.