GGTP stands for gamma-glutamyl transferase, which is an enzyme primarily found in the liver and certain other tissues such as the kidneys and pancreas. It plays a crucial role in the metabolism of glutathione, a key antioxidant involved in cellular protection against oxidative stress. Additionally, GGTP is involved in the transport of amino acids across cell membranes.
Clinically, GGTP is commonly measured in blood tests to assess liver function and diagnose certain diseases and conditions. Elevated levels of GGTP in the blood may indicate liver damage, as this enzyme is released into the bloodstream when liver cells are injured or inflamed. Conditions such as hepatitis, cirrhosis, liver tumors, and drug-induced liver damage often lead to increased GGTP levels. Additionally, GGTP levels may be elevated in conditions unrelated to the liver, such as alcohol abuse, pancreatitis, certain medications, and heart disease.
Monitoring GGTP levels can also be useful in assessing the effectiveness of certain medications, particularly those known to cause liver toxicity. By measuring GGTP levels at regular intervals during treatment, doctors can determine if the drug is causing any adverse effects on liver function.
In summary, GGTP is an enzyme largely found in the liver and is used as a marker to evaluate liver health and function. Elevated GGTP levels can be indicative of liver damage, certain diseases, medication toxicity, or other conditions, and regular monitoring of GGTP levels can aid in the diagnosis and management of various medical conditions.