HLA DR Meaning and
Definition
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HLA DR, also known as Human Leukocyte Antigen DR, refers to a group of genes that code for cell surface proteins called Human Leukocyte Antigen (HLA) class II molecules. These molecules are an important part of the immune system and are found on certain immune cells, including B cells, macrophages, and dendritic cells.
HLA DR plays a crucial role in immune recognition and response. It functions by presenting antigens derived from pathogens, such as bacteria or viruses, to immune cells known as T cells. This process is vital for the initiation of an immune response, as it allows T cells to recognize and eliminate invading pathogens.
Furthermore, HLA DR molecules also contribute to the regulation of immune responses. They help to determine whether the immune system should respond to a specific antigen, preventing the immune system from overreacting or attacking the body's own cells.
HLA DR is highly polymorphic, meaning that there are numerous variations or alleles within the population. This extensive diversity allows the immune system to respond to a wide range of antigens. Genetic variation within the HLA DR genes is associated with susceptibility or resistance to certain diseases, including autoimmune disorders, infectious diseases, and even cancer.
Understanding the function and variation of HLA DR molecules is crucial for studying and predicting immune responses, as well as for developing personalized medicine approaches that can account for an individual's specific HLA genotype.
Common Misspellings for HLA DR
- hladr
- hlla dr
- hlaa dr
- xLA DR
- lLA DR
- iLA DR
- HdA DR
- HhA DR
- HnA DR
- HmA DR
- HLi DR
- HLe DR
- HLc DR
- HLA0DR
- HLA tR
- HLA lR
- HLA Dz
- h la dr
- hl a dr
- hla d r
Etymology of HLA DR
The acronym HLA DR stands for Human Leukocyte Antigen-DR, which is a protein complex found on the surface of cells. HLA molecules play a crucial role in the immune system by presenting foreign substances, called antigens, to immune cells, allowing the body to mount an immune response against pathogens.
The term "HLA" originates from the Human Leukocyte Antigen system, first identified and named by Jean Dausset in the mid-20th century. Dausset discovered a set of cell surface antigens that were capable of stimulating immune responses, particularly in leukocytes (white blood cells). He named this group of antigens the Human Leukocyte Antigen (HLA) system.
The "DR" component of HLA DR refers specifically to the class II region of the HLA system.
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