INDOXYLURIA Meaning and
Definition
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Indoxyluria is a medical condition characterized by the presence of excessive levels of indole-based compounds, particularly indoxyl sulfate, in the urine. Indoxyl sulfate is formed by the breakdown of dietary proteins in the intestine and further metabolized by the liver, before being excreted in the urine. This condition is typically associated with impaired renal function or defects in the metabolism of tryptophan, an amino acid that serves as a precursor for indole compounds.
The buildup of indoxyl sulfate in the urine usually occurs due to a dysfunction in the kidneys' ability to effectively filter and excrete these waste products. Such dysfunction may result from various underlying causes, including genetic disorders, kidney disease, or impaired renal function due to advanced age. Indoxyluria can also be a consequence of certain medications that interfere with normal kidney function or affect the metabolism of tryptophan.
Symptoms of indoxyluria may not be immediately apparent, but in some cases, individuals may experience darkened or discolored urine, foul-smelling urine, or an increased frequency of urination. If left untreated, indoxyluria can potentially lead to more severe complications, such as kidney stones or renal failure.
Treatment approaches for indoxyluria generally involve addressing the underlying cause, such as managing kidney disease or modifying medications. Dietary adjustments may also play a role, with recommendations to reduce protein intake or follow a low-tryptophan diet. In some cases, medications that enhance kidney function or assist in the metabolism of indole compounds may be prescribed to alleviate symptoms and improve overall renal health. Regular monitoring and follow-up with healthcare professionals are crucial to managing indoxyluria effectively.
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The excretion of indoxyl, especially indoxyl sulphate, in the urine; indicanuria.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
Common Misspellings for INDOXYLURIA
- indoxyluraa
- indoxylurma
- indoxylurha
- indoxylurii
- indoxylurie
- indoxyluric
- indewxyluria
- induexyluria
- i ndoxyluria
- in doxyluria
- ind oxyluria
- indo xyluria
- indox yluria
- indoxy luria
- indoxyl uria
- indoxylu ria
- indoxylur ia
- indoxyluri a
Etymology of INDOXYLURIA
The word "indoxyluria" is derived from three components: "indoxyl", "ur", and "ia".
1. "Indoxyl" refers to a chemical compound derived from the amino acid tryptophan. It is commonly found in the urine of mammals as a result of tryptophan metabolism.
- The term "indoxyl" itself comes from a combination of "indigo" and "oxy-" ("-yl" being a suffix denoting a functional group). "Indigo" refers to a blue dye used historically in textile production, and the prefix "oxy-" indicates the presence of oxygen.
2. "Ur" refers to urine, the liquid waste excreted by the kidneys.
3. "Ia" is a suffix commonly used to denote a condition or state of being.
