KETOLYSIS Meaning and
Definition
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Ketolysis is a biochemical process that occurs in the body to break down ketone bodies for energy production. Ketones, specifically acetoacetate and β-hydroxybutyrate, are formed as an alternative fuel source when there is a shortage of glucose in the body, such as during prolonged fasting, low carbohydrate intake, or in individuals with untreated diabetes.
During ketolysis, these circulating ketone bodies are transported from the liver to cells throughout the body, where they are converted back into acetyl-CoA. Acetyl-CoA can then enter the citric acid cycle (also known as the Krebs cycle or TCA cycle) to generate ATP, the energy currency of the cell. This provides a crucial energy source, particularly for organs like the brain and heart, which preferentially utilize ketones during periods of glucose scarcity.
Ketolysis is tightly regulated by various enzymes and metabolic pathways to ensure that ketone bodies are utilized efficiently. The process involves the activation of specific enzymes, such as thiophorase and β-ketoacyl-CoA transferase, which facilitate the breakdown of ketones. The resulting acetyl-CoA can either be completely oxidized for energy production or used for the synthesis of other molecules, depending on the energy demands of the body.
Disruptions in ketolysis can occur in certain metabolic disorders, causing an imbalance of ketone bodies and leading to conditions like ketoacidosis. Ketolysis is an essential metabolic pathway that allows the body to adapt and maintain energy production during periods of limited glucose availability.
Common Misspellings for KETOLYSIS
- jetolysis
- metolysis
- letolysis
- oetolysis
- ietolysis
- kwtolysis
- kstolysis
- kdtolysis
- krtolysis
- k4tolysis
- k3tolysis
- kerolysis
- kefolysis
- kegolysis
- keyolysis
- ke6olysis
- ke5olysis
- ketilysis
- ketklysis
- ketllysis
Etymology of KETOLYSIS
The word "ketolysis" is derived from a combination of two roots: "keto-" and "-lysis".
1. "Keto-" is derived from the Greek word "ketos", meaning "ketone". Ketones are organic compounds characterized by a carbonyl group attached to two carbon atoms. They are produced during the metabolism of fats and are used as an alternative energy source by the body in the absence of glucose.
2. "-Lysis" is also derived from Greek and means "breaking down" or "separation". It is commonly used in scientific and medical terminology to denote a process in which molecules or substances are broken down or decomposed.
When combined, "keto-" and "-lysis" in "ketolysis" refer to the metabolic process of breaking down ketones, which are produced during ketogenesis, and converting them back into energy.
