KININASE I Meaning and
Definition
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Kininase I, also known as angiotensin-converting enzyme (ACE), is an enzyme primarily found in the lungs and blood vessels that plays a vital role in the regulation of blood pressure and fluid balance within the body. Its main function is to convert angiotensin I to angiotensin II.
Angiotensin I is produced by the action of renin, an enzyme secreted by the kidneys. Kininase I acts upon angiotensin I by removing a dipeptide from its structure, resulting in the formation of angiotensin II. Angiotensin II is a potent vasoconstrictor, meaning it causes the blood vessels to narrow. As a result, it increases peripheral resistance, raises blood pressure, and stimulates the release of aldosterone, which promotes sodium and water reabsorption by the kidneys.
Additionally, kininase I is responsible for the degradation of bradykinin, a peptide that causes vasodilation and promotes pain sensation. By breaking down bradykinin, kininase I helps regulate blood pressure and reduce pain sensitivity.
Inhibitors of kininase I, such as ACE inhibitors, are commonly used to treat hypertension and heart failure. These medications block the action of kininase I, leading to increased levels of bradykinin and decreased levels of angiotensin II, resulting in vasodilation and lowered blood pressure. The inhibition of kininase I has also been shown to have beneficial effects on kidney function and reduce the risk of certain cardiovascular conditions.
Common Misspellings for KININASE I
- jininase i
- mininase i
- lininase i
- oininase i
- iininase i
- kuninase i
- kjninase i
- kkninase i
- koninase i
- k9ninase i
- k8ninase i
- kibinase i
- kiminase i
- kijinase i
- kihinase i
- kinunase i
- kinjnase i
- kinknase i
- kinonase i
- kin9nase i
Etymology of KININASE I
The word "Kininase I" is derived from the combination of two terms: "kinin" and "ase".
1. Kinin: The term "kinin" refers to a group of peptides that play a role in inflammation, blood pressure regulation, pain perception, and various physiological processes. The word "kinin" itself originated from the Greek word "kinein", which means "to move" or "to set in motion". These peptides were first discovered in the early 20th century through studies on blood plasma and their role in causing vasodilation and smooth muscle contraction.
2. -ase: The suffix "-ase" is commonly used in biology and refers to an enzyme. Enzymes are biological molecules that catalyze or speed up chemical reactions within living organisms.
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