KINOME Meaning and
Definition
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The term "kinome" refers to the complete set of all protein kinases present in an organism or cell. A protein kinase is an enzyme that catalyzes the transfer of a phosphate group from adenosine triphosphate (ATP) to a target protein, known as a substrate. This process is called phosphorylation and plays a crucial role in cellular signaling pathways, regulating various biological functions such as cell growth, division, differentiation, and apoptosis.
The kinome encompasses a vast array of protein kinases, which are classified into different families based on their structural and functional characteristics. These families include receptor tyrosine kinases (RTKs), serine/threonine kinases, tyrosine kinases, and atypical kinases.
The study of the kinome is essential in understanding the complex network of cellular signaling and its implications in health and disease. Mapping and profiling the kinome can provide valuable insights into signaling cascades, identifying potential therapeutic targets for drug development, and diagnosing diseases. Techniques such as kinome-wide screening using small molecule inhibitors or mass spectrometry are employed to analyze the activities and interactions of protein kinases within the kinome.
Overall, the kinome represents a dynamic and intricate system of protein kinases that orchestrate cellular processes and serve as crucial components in maintaining cellular homeostasis.
Common Misspellings for KINOME
- kanome
- kinone
- kinom
- jinome
- minome
- linome
- oinome
- iinome
- kunome
- kjnome
- kknome
- konome
- k9nome
- k8nome
- kibome
- kimome
- kijome
- kihome
- kinime
- kinkme
Etymology of KINOME
The term "kinome" is a combination of two words: "kinase" and "genome".
"Kinase" refers to a type of enzyme that catalyzes the transfer of a phosphate group from a molecule, typically ATP (adenosine triphosphate), to another molecule. Kinases are vital in cellular signal transduction processes, regulating various cellular functions such as cell growth, metabolism, and proliferation.
"Genome" refers to the complete set of genetic material or genes present in an organism.
The word "kinome" was coined to describe the entire set of kinases encoded in an organism's genome. It represents the global collection of kinases that are responsible for regulating cellular processes through phosphorylation and signaling pathways. The term "kinome" was first proposed in an article published in 2000 by Gerard Manning and his colleagues in the journal Science Signaling.
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