The LCM Lassa Complex Viruses (LCM-LASV) are a group of viral pathogens that belong to the family Arenaviridae and the genus Mammarenavirus. These viruses are associated with two distinct diseases: Lymphocytic Choriomeningitis (LCM) and Lassa fever.
LCM-LASV viruses are named after the diseases they cause. Lymphocytic Choriomeningitis is a viral infection that affects rodents and can be transmitted to humans through contact with infected animals, particularly by inhalation of aerosolized urine, droppings, or saliva. The illness is characterized by flu-like symptoms such as fever, muscle aches, headache, and malaise. In severe cases, it can lead to complications like aseptic meningitis or encephalitis.
Lassa fever, on the other hand, is primarily prevalent in West Africa and is transmitted to humans through contact with infected rodents, particularly the multimammate rat. It can also spread through person-to-person contact. Lassa fever can cause a wide range of symptoms, from mild fever and malaise to more severe manifestations like hemorrhagic fever, which can lead to internal bleeding, organ failure, and death.
LCM-LASV viruses are enveloped, single-stranded RNA viruses. They have a segmented genome consisting of two segments, which encode for various viral proteins including the nucleoprotein, glycoprotein, and polymerase. These viruses are known for their ability to persistently infect and replicate within their host, leading to chronic infections in rodents and potential outbreaks in humans.
In conclusion, LCM Lassa Complex Viruses (LCM-LASV) are a group of viruses that cause two distinct diseases: Lymphocytic Chori
