How Do You Spell LYSINE 2 OXOGLUTARATE DIOXYGENASE?

Pronunciation: [lˈa͡ɪsa͡ɪn tˈuː ˈɒksəɡlˌuːtɐɹˌe͡ɪt da͡ɪˈɒksɪd͡ʒənˌe͡ɪs] (IPA)

Lysine 2-oxoglutarate dioxygenase is an enzyme that plays a crucial role in the synthesis of collagen. The spelling of this word can be challenging due to its complex structure. The International Phonetic Alphabet (IPA) phonetic transcription can help to explain the pronunciation of this term. The word "lysine" is pronounced as /ˈlaɪsiːn/, "oxoglutarate" as /ˌɒksəʊˈɡluːtəreɪt/, and "dioxygenase" as /daɪˈɒksɪdʒəneɪs/. Understanding the correct phonetic pronunciation of this enzyme's name can aid in better communication and understanding within the scientific community.

LYSINE 2 OXOGLUTARATE DIOXYGENASE Meaning and Definition

  1. Lysine 2-oxoglutarate dioxygenase is an enzyme that plays a crucial role in the biosynthesis of collagen, an essential protein component of connective tissues, bones, and organs. This enzyme is also known as prolyl hydroxylase domain-containing protein 2 (PHD2) or prolyl-4-hydroxylase alpha subunit 2 (P4HA2).

    The function of lysine 2-oxoglutarate dioxygenase is to catalyze the hydroxylation of specific proline residues within collagen peptides. This hydroxylation process is critical for stabilizing collagen molecules and ensuring their proper assembly and function. Additionally, this enzyme is involved in regulating the degradation of hypoxia-inducible factor (HIF), a transcription factor that controls the response to low oxygen conditions.

    In terms of its molecular structure, lysine 2-oxoglutarate dioxygenase belongs to the family of iron-containing enzymes known as dioxygenases. It requires iron, alpha-ketoglutarate, and molecular oxygen as cofactors to perform its enzymatic activity. The reaction catalyzed by lysine 2-oxoglutarate dioxygenase results in the transfer of molecular oxygen to the proline residue of collagen, leading to the formation of hydroxyproline.

    Mutations or dysregulation of this enzyme can lead to various disorders, including hereditary collagen disorders like Osteogenesis Imperfecta and Ehlers-Danlos syndrome. Understanding and studying lysine 2-oxoglutarate dioxygenase have significant implications in the field of medicine and molecular biology, as it is closely associated with collagen-related diseases and potential therapeutic intervention.

Common Misspellings for LYSINE 2 OXOGLUTARATE DIOXYGENASE

  • kysine 2 oxoglutarate dioxygenase
  • pysine 2 oxoglutarate dioxygenase
  • oysine 2 oxoglutarate dioxygenase
  • ltsine 2 oxoglutarate dioxygenase
  • lgsine 2 oxoglutarate dioxygenase
  • lhsine 2 oxoglutarate dioxygenase
  • lusine 2 oxoglutarate dioxygenase
  • l7sine 2 oxoglutarate dioxygenase
  • l6sine 2 oxoglutarate dioxygenase
  • lyaine 2 oxoglutarate dioxygenase
  • lyzine 2 oxoglutarate dioxygenase
  • lyxine 2 oxoglutarate dioxygenase
  • lydine 2 oxoglutarate dioxygenase
  • lyeine 2 oxoglutarate dioxygenase
  • lywine 2 oxoglutarate dioxygenase
  • lysune 2 oxoglutarate dioxygenase
  • lysjne 2 oxoglutarate dioxygenase
  • lyskne 2 oxoglutarate dioxygenase
  • lysone 2 oxoglutarate dioxygenase
  • lys9ne 2 oxoglutarate dioxygenase