How Do You Spell MET TRNA LIGASE?

Pronunciation: [mˈɛt tˈiː ˌɑːɹˌɛnˈe͡ɪ lˈɪɡe͡ɪs] (IPA)

The spelling of the word "Met tRNA Ligase" can be deciphered through the International Phonetic Alphabet (IPA). "Met" is pronounced as /mɛt/, where the "e" is pronounced as the "e" in "get". "tRNA" is pronounced as /tiːˌɑrˈɛn/, with a long "i" sound and the emphasis on the second syllable. Finally, "Ligase" is pronounced as /ˈlaɪˌɡeɪs/, with a long "i" sound in "lig" and the emphasis on the first syllable. Therefore, "Met tRNA Ligase" is pronounced as /mɛt tiːˌɑrˈɛn ˈlaɪˌɡeɪs/.

MET TRNA LIGASE Meaning and Definition

  1. Met-tRNA ligase, also known as methionyl-tRNA synthetase, is an enzyme that plays a crucial role in protein synthesis by catalyzing the attachment of the amino acid methionine to its corresponding transfer RNA (tRNA). It belongs to the family of ligases, which are enzymes that create covalent bonds between two molecules.

    Met-tRNA ligase specifically recognizes and binds to both methionine and the specific tRNA molecule with an anticodon that corresponds to methionine. This enzyme ensures the accuracy and fidelity of protein synthesis by selectively attaching methionine to its corresponding tRNA molecule, preventing the incorporation of incorrect amino acids into the growing polypeptide chain.

    The catalytic process of Met-tRNA ligase involves two distinct steps. First, it activates methionine by attaching it to adenosine monophosphate (AMP), creating a complex called methionyl-adenylate. In the second step, methionyl-adenylate is transferred from AMP to the specific tRNA, forming a covalent bond between the carboxyl group of methionine and the 3' end of the tRNA molecule.

    Met-tRNA ligase is found in all living organisms, from bacteria to eukaryotes, highlighting its essential role in protein synthesis. Mutations or dysregulation of this enzyme can lead to impaired protein synthesis and various cellular dysfunction. Therefore, understanding the precise mechanism and regulation of Met-tRNA ligase has clinical implications in fields such as drug development and gene therapy.

Common Misspellings for MET TRNA LIGASE

  • net trna ligase
  • ket trna ligase
  • jet trna ligase
  • mwt trna ligase
  • mst trna ligase
  • mdt trna ligase
  • mrt trna ligase
  • m4t trna ligase
  • m3t trna ligase
  • mer trna ligase
  • mef trna ligase
  • meg trna ligase
  • mey trna ligase
  • me6 trna ligase
  • me5 trna ligase
  • met rrna ligase
  • met frna ligase
  • met grna ligase
  • met yrna ligase
  • met 6rna ligase

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