How Do You Spell MINIMUM INHIBITORY CONCENTRATION?

Pronunciation: [mˈɪnɪməm ɪnhˈɪbɪtəɹˌi kˌɒnsəntɹˈe͡ɪʃən] (IPA)

The term "Minimum Inhibitory Concentration" (MIC) refers to the smallest amount of a substance that can completely prevent the growth of a particular microorganism. Pronounced /ˈmɪnɪməm ɪnˌhɪbɪtəri kənˌsɛnˈtreɪʃən/, the word "minimum" is spelled with the letter "i" after the "n" and the letter "o" after the "m". The word "inhibitory" contains the letter "h" which is silent, while the word "concentration" is spelled with the letter "c" and not the letter "s". The IPA phonetic transcription assists with understanding the correct pronunciation of this complex term.

MINIMUM INHIBITORY CONCENTRATION Meaning and Definition

  1. Minimum Inhibitory Concentration (MIC) is a term used in microbiology and pharmacology to describe the lowest concentration of an antimicrobial agent, such as an antibiotic or antifungal drug, that can inhibit the growth or activity of a specific microorganism. It is a quantitative parameter that helps in determining the potency and effectiveness of antimicrobial agents against microbial pathogens.

    MIC is determined through laboratory tests called susceptibility testing or antimicrobial susceptibility testing (AST), where different dilutions or concentrations of a drug are tested against a known concentration of microorganisms. The MIC value is then recorded as the lowest concentration of the drug that prevents visible growth of the microorganism after a specific incubation period.

    MIC is an essential measure for understanding the susceptibility of microorganisms to antibiotics or other antimicrobial agents. It aids in determining the appropriate dosage or concentration of a drug required to effectively treat an infection. The MIC value can also be compared with established breakpoints or interpretive criteria to classify microorganisms as susceptible, intermediate, or resistant to a particular drug.

    MIC values are commonly reported in micrograms per milliliter (μg/mL) or other equivalent units and are used to guide clinical decision-making, such as choosing the most appropriate antibiotic for treating an infection. The determination of MIC values helps to prevent under-dosing or over-dosing of antimicrobial agents, thereby minimizing the development of drug resistance and improving patient outcomes.

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