Morvan Chorea, also known as Morvan's syndrome or Morvan's fibrillary chorea, is a rare neurological disorder characterized by a combination of symptoms including muscle twitching, stiffness, and uncontrolled contractions or jerks (chorea). It is named after the French physician Augustin Morvan, who first described the condition in the late 19th century.
The exact cause of Morvan Chorea is not fully understood but is believed to be associated with autoimmune processes, where the body's immune system mistakenly attacks healthy tissues, including the nerves. This can result in the disruption of normal nerve signals and lead to the characteristic symptoms.
Individuals with Morvan Chorea often experience muscle cramps, muscle pain, and muscle weakness, particularly in the limbs. In addition to motor symptoms, they may also present with autonomic dysfunction, including excessive sweating, rapid heart rate, and altered blood pressure.
Diagnosis of Morvan Chorea typically involves clinical evaluation, medical history assessment, and various tests such as electromyography (EMG) to assess the electrical activity of muscles and autoantibody testing to identify specific antibodies associated with the disorder.
Treatment for Morvan Chorea aims to alleviate symptoms and may involve the use of medications such as anti-seizure drugs, muscle relaxants, and immunomodulatory agents to suppress immune responses. Physical therapy and occupational therapy can also be beneficial in managing symptoms and improving quality of life.
Though Morvan Chorea can be a debilitating condition, with appropriate medical intervention and symptom management, individuals affected by this disorder can experience significant improvement in their overall functioning.
