NAD Agmatine ADP Ribosyltransferase, also known as AGAR or Agmatine ADP-ribosyltransferase, is an enzyme that plays a vital role in the metabolism of agmatine. Agmatine is a naturally occurring compound found in various tissues of organisms, including mammals, bacteria, and plants, and it is involved in several physiological functions.
The function of NAD Agmatine ADP Ribosyltransferase is to catalyze the transfer of ADP-ribose from nicotinamide adenine dinucleotide (NAD+) to agmatine, resulting in the formation of NADH and N-(ADP-D-ribosyl)-agmatine. This enzymatic reaction is a form of ADP-ribosylation, a process that involves the addition of an ADP-ribose group to a target molecule.
AGAR is commonly found in bacteria, where it helps regulate the levels of agmatine within the cell. It is the key enzyme that converts agmatine into N-(ADP-D-ribosyl)-agmatine, thereby contributing to the regulation of agmatine homeostasis.
The ADP-ribosylation of agmatine mediated by NAD Agmatine ADP Ribosyltransferase has been implicated in various biological processes, including cell signaling, gene expression, and responses to stress. The formation of N-(ADP-D-ribosyl)-agmatine can modify the function and activity of target proteins, leading to alterations in cellular processes.
In summary, NAD Agmatine ADP Ribosyltransferase is an enzyme that facilitates the transfer of ADP-ribose from NAD+ to agmatine, resulting in
