Pronunciation: [nˈɒma͡ɪfnsˌa͡ɪn mˈe͡ɪle͡ɪt] (IPA) 
Correct spelling for the English word "Nomifensine Maleate" is [nˈɒma͡ɪfnsˌa͡ɪn mˈe͡ɪle͡ɪt], [nˈɒmaɪfnsˌaɪn mˈeɪleɪt], [n_ˈɒ_m_aɪ_f_n_s_ˌaɪ_n m_ˈeɪ_l_eɪ_t] (IPA phonetic alphabet).
Nomifensine Maleate is a compound used in pharmacology and medicine. It is a salt form of nomifensine, an antidepressant and psychostimulant drug. Nomifensine Maleate is primarily used for the treatment of depressive disorders, including major depression and bipolar depression.
Nomifensine Maleate acts by inhibiting the reuptake of norepinephrine, dopamine, and to a lesser extent, serotonin in the brain. By preventing the reabsorption of these neurotransmitters into the nerve cells, Nomifensine Maleate increases their concentration in the synaptic cleft, which then enhances their effects on mood regulation and neurotransmission.
The compound is typically administered orally in the form of tablets or capsules. Nomifensine Maleate is metabolized by the liver and eliminated from the body through urine and feces. It has a relatively long half-life, allowing for once or twice-daily dosing.
While effective in treating depression, Nomifensine Maleate is also associated with potential side effects. These may include insomnia, nervousness, restlessness, mild euphoria, increased energy, and appetite suppression. It may also cause dizziness, headache, gastrointestinal disturbances, and changes in blood pressure.
Despite its efficacy, the use of Nomifensine Maleate has declined over the years due to the emergence of newer antidepressant drugs with improved safety profiles. Moreover, it has been linked to rare cases of hepatotoxicity, which led to its withdrawal from the market in several countries. Nomifensine Maleate should only be used under the supervision and prescription of a qualified healthcare professional.
The word "Nomifensine Maleate" is a combination of the drug's generic name and the specific salt form in which it is administered.
- "Nomifensine" is derived from the Latin roots "nominis" (meaning 'name') and "fens" (meaning 'away from'), indicating that this drug is intended to move away or alleviate a certain condition. It was specifically chosen as a brand name for a psychiatric medication.
- "Maleate" refers to the specific salt form of the drug called maleic acid. "Maleate" is derived from "maleic acid", which itself derives from the Latin word "malum" meaning 'apple'. The term originated due to the apple-like odor of maleic acid. In pharmaceutical terms, maleate salts are often used to improve the bioavailability or stability of certain medications.
