How Do You Spell PARA HYDROXYPHENYLPYRUVATE HYDROXYLASE?

Pronunciation: [pˈaɹə hˈa͡ɪdɹəksɪfˌiːna͡ɪlpˌɪɹuːvˌe͡ɪt hˈa͡ɪdɹəksˌɪle͡ɪs] (IPA)

The spelling of "para Hydroxyphenylpyruvate Hydroxylase" is complex, but can be deciphered using the International Phonetic Alphabet (IPA) transcription. The "p" in "para" is pronounced as the English "p" sound. "Hydroxyphenylpyruvate" is pronounced with a schwa sound for the first "y" and "u" and the stress on the "a". Additionally, "Hydroxylase" has the stress on the second syllable and is pronounced with an "ih" sound for the letter "y". Understanding the IPA can help with accurate pronunciation and spelling of scientific terms.

PARA HYDROXYPHENYLPYRUVATE HYDROXYLASE Meaning and Definition

1. Para hydroxyphenylpyruvate hydroxylase (HPPH) is an enzyme that plays a crucial role in a biochemical pathway called the tyrosine metabolism pathway. It catalyzes the conversion of para hydroxyphenylpyruvate (pHPP) to homogentisate (HG). This enzyme is encoded by the HGD gene.

   The tyrosine metabolism pathway is responsible for the breakdown of the amino acid tyrosine, which is an essential building block for various compounds in the body. HPPH specifically acts in the synthesis of homogentisate, which is a key intermediate in the pathway.

   HPPH belongs to the family of alpha-ketoacid dependentdioxygenases and uses a non-heme iron as a cofactor. Additionally, it requires molecular oxygen and alpha-ketoglutarate as co-substrates to carry out the hydroxylation reaction.

   Mutations in the HGD gene, which encodes HPPH, can lead to a rare genetic disorder called alkaptonuria. In this condition, the activity of HPPH is impaired, leading to the accumulation of undegraded pHPP and its subsequent conversion to homogentisic acid. Homogentisic acid can build up in various tissues and body fluids, leading to characteristic symptoms such as dark urine, ochronosis (bluish-black pigmentation of tissues), and joint and connective tissue problems.

   In summary, para hydroxyphenylpyruvate hydroxylase (HPPH) is an enzyme involved in the tyrosine metabolism pathway. It catalyzes the conversion of para hydroxyphenylpyruvate (pHPP) to homogentisate, and

Common Misspellings for PARA HYDROXYPHENYLPYRUVATE HYDROXYLASE

• oara hydroxyphenylpyruvate hydroxylase
• lara hydroxyphenylpyruvate hydroxylase
• -ara hydroxyphenylpyruvate hydroxylase
• 0ara hydroxyphenylpyruvate hydroxylase
• pzra hydroxyphenylpyruvate hydroxylase
• psra hydroxyphenylpyruvate hydroxylase
• pwra hydroxyphenylpyruvate hydroxylase
• pqra hydroxyphenylpyruvate hydroxylase
• paea hydroxyphenylpyruvate hydroxylase
• pada hydroxyphenylpyruvate hydroxylase
• pafa hydroxyphenylpyruvate hydroxylase
• pata hydroxyphenylpyruvate hydroxylase
• pa5a hydroxyphenylpyruvate hydroxylase
• pa4a hydroxyphenylpyruvate hydroxylase
• parz hydroxyphenylpyruvate hydroxylase
• pars hydroxyphenylpyruvate hydroxylase
• parw hydroxyphenylpyruvate hydroxylase
• parq hydroxyphenylpyruvate hydroxylase
• para gydroxyphenylpyruvate hydroxylase
• para bydroxyphenylpyruvate hydroxylase