PEGYLATE Meaning and
Definition
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PEGylate is a verb that refers to the process of attaching a polyethylene glycol (PEG) chain or polymer to a molecule. PEGylation is a popular technique used in the field of medicine and biotechnology to modify drugs, proteins, or other biomolecules. The addition of PEG chains can alter the properties of the molecule, resulting in improved stability, solubility, bioavailability, and prolonged circulation time in the body.
The process of PEGylation involves the covalent attachment of PEG chains to the target molecule. This can be achieved by various chemical methods, such as conjugation through reactive functional groups present on the target molecule, or through enzymatic or genetic engineering techniques. PEGylation can be used to modify small molecules, peptides, antibodies, enzymes, and other biologically active molecules.
PEGylated molecules often exhibit reduced immunogenicity, increased resistance to enzymatic degradation, and improved pharmacokinetic properties, making them attractive candidates for drug delivery systems or therapeutic agents. The PEG chains provide a protective barrier around the molecule, preventing recognition by the immune system and minimizing rapid clearance from the body.
PEGylation has been extensively studied and utilized in the development of biopharmaceuticals, nanomedicine, and drug delivery systems. Its application has significantly contributed to the improvement of therapeutic efficacy and safety profiles of various drugs and biomolecules.
Common Misspellings for PEGYLATE
- oegylate
- legylate
- -egylate
- 0egylate
- pwgylate
- psgylate
- pdgylate
- prgylate
- p4gylate
- p3gylate
- pefylate
- pevylate
- pebylate
- pehylate
- peyylate
- petylate
- pegtlate
- pegglate
- peghlate
- pegulate
Etymology of PEGYLATE
The word "PEGylate" is derived from the acronym PEG (polyethylene glycol) and the suffix "-ylate". PEG is a polymer compound composed of repeating units of ethylene glycol. The term "PEGylation" refers to a process in which PEG molecules are attached to another substance (such as a drug or protein) to enhance its properties, such as stability, solubility, or bioavailability. The word "PEGylate" specifically refers to the action of attaching PEG molecules to a substance.
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