POLSTIGMINE Meaning and
Definition
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Polstigmine is a medication classified as a reversible cholinesterase inhibitor, primarily used in the treatment of myasthenia gravis. Myasthenia gravis is a neuromuscular disorder characterized by muscle weakness and fatigue due to an abnormal immune response affecting the communication between nerves and muscles. Polstigmine works by blocking the action of the enzyme acetylcholinesterase, which is responsible for breaking down the neurotransmitter acetylcholine. By inhibiting acetylcholinesterase, polstigmine increases the concentration and duration of action of acetylcholine, leading to improved muscle strength and function.
Polstigmine is typically administered orally or through injection and is rapidly absorbed into the bloodstream, reaching peak concentrations within approximately 30 minutes to 2 hours. The medication is metabolized in the liver and cleared through urine. Common side effects of polstigmine include gastrointestinal disturbances, such as nausea, vomiting, and diarrhea, as well as increased salivation and sweating.
It is important to note that polstigmine should be used under medical supervision, as improper dosage or administration can result in cholinergic crisis, a potentially life-threatening condition characterized by excessive activation of the cholinergic system. In cases of overdose or adverse reactions, immediate medical attention should be sought. Polstigmine should not be used in individuals with known hypersensitivity to the medication or those with mechanical obstruction of the gastrointestinal or urinary tracts.
Common Misspellings for POLSTIGMINE
- oolstigmine
- lolstigmine
- -olstigmine
- 0olstigmine
- pilstigmine
- pklstigmine
- pllstigmine
- pplstigmine
- p0lstigmine
- p9lstigmine
- pokstigmine
- popstigmine
- poostigmine
- polatigmine
- polztigmine
- polxtigmine
- poldtigmine
- poletigmine
- polwtigmine
- polsrigmine
