QUINOLINATE Meaning and
Definition
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Quinolinate is a chemical compound with the molecular formula C9H6NO2. It is an organic compound that belongs to the class of aromatic nitrogen-containing heterocycles. Quinolinate is derived from pyridine through a process called quinoline synthesis, where a hydroxyl group is added to the structure.
In terms of its physical properties, quinolinate appears as a yellow powder or crystals. It is sparingly soluble in water but dissolves readily in various organic solvents like ethanol and acetone.
Quinolinate has received attention in scientific research due to its role as an essential intermediate in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a coenzyme involved in numerous metabolic reactions. It acts as a precursor during the kynurenine pathway, which is responsible for the synthesis of NAD+ from tryptophan and is crucial for cell metabolism and energy production.
Furthermore, quinolinate has been found to be a potential neurotransmitter and an agonist of the N-methyl-D-aspartate (NMDA) receptor, a type of glutamate receptor in the brain. It has been implicated in neurodegenerative diseases like Alzheimer's and Huntington's disease, where increased levels of quinolinate have been observed in affected regions.
In summary, quinolinate is an organic compound involved in the biosynthesis of NAD+ and acts as a neurotransmitter in the brain. Its chemical structure consists of a heterocyclic ring with a hydroxyl group attached. Further research is ongoing to understand its biological functions and its potential implications in various diseases.
Common Misspellings for QUINOLINATE
- 1uinolinate
- 2uinolinate
- wuinolinate
- auinolinate
- qyinolinate
- qhinolinate
- qjinolinate
- qiinolinate
- q8inolinate
- q7inolinate
- quunolinate
- qujnolinate
- quknolinate
- quonolinate
- qu9nolinate
- qu8nolinate
- quibolinate
- quimolinate
- quijolinate
- quiholinate
Etymology of QUINOLINATE
The word quinolinate is derived from quinoline, which in turn originates from the German word Chinolin. The term Chinolin was coined by the German chemist August Wilhelm von Hofmann in 1842. The word Chinolin was derived by Hofmann from the Latin word cinchona, which refers to the bark of the cinchona tree that is used to produce quinine. The suffix -ate is added to the end of quinolin to indicate that it is the anion of an acid, forming the term quinolinate.
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