SCID MICE Meaning and
Definition
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SCID (Severe Combined Immunodeficiency) mice, also known as SCID-hu mice, are a widely used genetic strain of laboratory mice that have a severe immune deficiency, resembling the genetically inherited disease SCID seen in humans.
The acronym SCID refers to the condition in which the mice lack functional T lymphocytes, B lymphocytes, and natural killer cells, resulting in an impaired immune system. This immune deficiency is caused by a spontaneous mutation in both copies of the Prkdc (protein kinase, DNA-activated, catalytic polypeptide) gene, rendering them incapable of producing the protein essential for V(D)J recombination – the process required for the development of functional lymphocytes.
SCID mice serve as an invaluable model for the study of immune system development, diseases, and therapeutic interventions. Due to their immunodeficiency, they can be readily engrafted with human immune cells, tissues, or tumors, allowing the human immune system to develop, function, and interact within the murine host environment. This characteristic enables researchers to investigate various aspects of human immune responses, cancer biology, and the evaluation of potential immunotherapies, such as the engraftment of human hematopoietic stem cells for the treatment of blood disorders or the testing of human-specific drugs.
SCID mice have significantly contributed to the advancements in understanding immune system function and the development of novel therapies, making them an essential tool in biomedical research.
Common Misspellings for SCID MICE
- acid mice
- zcid mice
- xcid mice
- dcid mice
- ecid mice
- wcid mice
- sxid mice
- svid mice
- sfid mice
- sdid mice
- scud mice
- scjd mice
- sckd mice
- scod mice
- sc9d mice
- sc8d mice
- scis mice
- scix mice
- scic mice
- scif mice
Etymology of SCID MICE
"SCID" in SCID mice stands for Severe Combined Immunodeficiency.ice" refers to the strain of laboratory mice in which this immune deficiency condition was observed.
The word "immunodeficiency" is derived from the prefix "immuno-" meaning "relating to the immune system" and the root "deficiency" meaning "lack or shortage". The term "immunodeficiency" describes a condition where the immune system is compromised, leading to increased susceptibility to infections and diseases.
The term "Severe Combined Immunodeficiency" refers to a specific type of immunodeficiency disorder characterized by a severe impairment in both the cellular and humoral immune responses. It is called "combined" because it affects multiple components of the immune system.
As for the word "mice", it simply refers to the type of laboratory mice that were found to have this specific immunodeficiency condition.
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