How Do You Spell STROMELYSIN 1?

Pronunciation: [stɹˈə͡ʊmlɪsˌɪn wˈɒn] (IPA)

Stromelysin 1 is a term used in the field of biochemistry referring to a specific enzyme known for its role in the degradation of extracellular matrix proteins. Its spelling can be explained using the International Phonetic Alphabet (IPA) as /stroʊmɛlɪsɪn wʌn/. The initial "str" sound is pronounced as a blend of "s" and "t" sounds, while the "y" in "Stromelysin" represents a vowel sound similar to the "i" in "bit". The "1" at the end indicates that it is the first of several similar enzymes identified.

STROMELYSIN 1 Meaning and Definition

  1. Stromelysin 1 is an enzyme that belongs to the matrix metalloproteinase (MMP) family. It is a zinc-dependent endopeptidase that plays a crucial role in tissue remodeling and degradation of extracellular matrix (ECM) components. Stromelysin 1 is primarily expressed by fibroblast-like cells and various connective tissue cells, including chondrocytes, endothelial cells, and macrophages.

    This enzyme is involved in a variety of physiological and pathological processes such as embryonic development, wound healing, and tissue repair. However, aberrant expression and activity of stromelysin 1 are associated with numerous diseases and disorders, including arthritis, cancer, and cardiovascular diseases.

    As an ECM-degrading enzyme, stromelysin 1 specifically targets different components of the ECM, including collagen types I, II, III, IV, and IX, proteoglycans, and elastin. It cleaves these proteins at specific sites, leading to the disruption and alteration of tissue architecture.

    The activity of stromelysin 1 is tightly regulated by various endogenous inhibitors, such as tissue inhibitors of metalloproteinase (TIMPs), which act as competitive inhibitors by binding to the enzyme's active site. Dysregulation of this balance between enzyme and inhibitor can result in pathological tissue remodeling and disease progression.

    Stromelysin 1 has been extensively studied for its potential as a therapeutic target in various diseases. Inhibitors of stromelysin 1 have been developed to mitigate excessive ECM degradation and subsequent tissue damage. Additionally, the expression of stromelysin 1 can serve as a biomarker for certain diseases, aiding in diagnosis and prognosis.

Common Misspellings for STROMELYSIN 1

  • atromelysin 1
  • ztromelysin 1
  • xtromelysin 1
  • dtromelysin 1
  • etromelysin 1
  • wtromelysin 1
  • srromelysin 1
  • sfromelysin 1
  • sgromelysin 1
  • syromelysin 1
  • s6romelysin 1
  • s5romelysin 1
  • steomelysin 1
  • stdomelysin 1
  • stfomelysin 1
  • sttomelysin 1
  • st5omelysin 1
  • st4omelysin 1
  • strimelysin 1
  • strkmelysin 1

Etymology of STROMELYSIN 1

The word "Stromelysin 1" has its origins in the field of biochemistry and molecular biology.

The prefix "strom-" refers to connective tissue, which comprises the extracellular matrix of various tissues in the body. Connective tissue is involved in supporting and connecting different structures and organs.

The main part of the word, "lysin", is derived from the term "lysine", which is an essential amino acid. Amino acids are the building blocks of proteins, and lysine plays a crucial role in protein synthesis and various metabolic processes.

The suffix "1" generally indicates that it is the first or an early-discovered member of a specific group or family. In this case, Stromelysin 1 represents a specific member of the matrix metalloproteinase (MMP) family, which are enzymes involved in the breakdown of the extracellular matrix.

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