Subcorneal pustular dermatosis, also known as Sneddon-Wilkinson disease, is a rare chronic skin disorder characterized by the presence of pustules that develop within the uppermost layer of the skin, known as the stratum corneum. It primarily affects middle-aged individuals, predominantly women, and often presents as recurrent episodes or a persistent condition.
The condition typically begins with the appearance of small, painless, and fluid-filled pustules that cluster together, forming patches or plaques on the skin. These pustules may rupture and release an amber-colored fluid, which eventually dries and crusts over, leading to the formation of scaly patches that may resemble impetigo or psoriasis. The affected areas are commonly found on the trunk, armpits, groin, and flexural regions.
The exact cause of subcorneal pustular dermatosis is still unclear, although it is believed to be an immune-mediated disorder with genetic predisposition. Certain triggering factors, such as infections, medications, hormonal changes, and emotional stress, may also contribute to the development or exacerbation of the condition.
Treatment options for subcorneal pustular dermatosis aim to reduce inflammation, control symptoms, and prevent relapses. Topical or systemic medications, including corticosteroids, antibiotics, dapsone, and immunosuppressants, may be prescribed depending on the severity and extent of the disease. Maintaining proper hygiene, avoiding potential irritants, and managing stress levels are also important in managing the condition.
While subcorneal pustular dermatosis is a chronic condition that may require long-term management, with proper treatment and care, the majority of individuals experience periods of remission and an overall improvement in their skin condition
