TC 25 GTP Binding Protein, also known as Tectonic family member 2 (TCTN2), is a protein that plays a crucial role in various biological processes. It is a member of the tectonic family of proteins, which are evolutionarily conserved and are primarily associated with the primary cilium, a cellular structure present on the surface of most vertebrate cells.
TC 25 GTP Binding Protein is involved in the regulation of cell development, cell migration, and maintenance of ciliary structure and function. It functions as a GTPase, which means it can bind to and hydrolyze guanosine triphosphate (GTP), a molecule that provides energy for cellular processes.
The binding and hydrolysis of GTP by TC 25 GTP Binding Protein play a vital role in signal transduction pathways. When GTP is bound to the protein, it is in an active state and can interact with other proteins to transmit signals inside the cell. Upon hydrolysis of GTP to guanosine diphosphate (GDP), TC 25 GTP Binding Protein becomes inactive and releases the signal.
Mutations or dysregulation of TC 25 GTP Binding Protein have been associated with various human diseases such as ciliopathies and polycystic kidney disease. Ciliopathies are a group of disorders characterized by abnormal function or structure of the primary cilium, leading to a variety of developmental and degenerative defects in multiple organs. Polycystic kidney disease is a genetic disorder in which multiple cysts form on the kidneys, leading to kidney enlargement and dysfunction.
Further research is being conducted to unravel the precise mechanisms and functions of TC 25 GTP Binding Protein, which may provide insights into the development of therapies for related
