TRPM8 Meaning and
Definition
-
TRPM8 refers to a transient receptor potential cation channel subfamily M member 8, which is a protein-coding gene involved in various physiological and cellular processes. TRPM8 is predominantly expressed in sensory neurons of the peripheral nervous system and is known as the cold and menthol receptor. It plays a crucial role in sensing and responding to cold temperatures, cooling sensations, and detecting certain chemical compounds like menthol.
The TRPM8 protein functions as a non-selective calcium-permeable channel within the cell membrane. When exposed to cold temperatures or menthol, TRPM8 channels open, allowing the influx of calcium ions into the cells, leading to the initiation of nerve signals. Activation of TRPM8 receptors induces cooling, analgesic, and antipruritic effects, making them essential in thermoregulation and the perception of cold sensations.
Apart from thermal sensation, TRPM8 also participates in other physiological activities such as pain modulation, inflammation, and even in certain cancer mechanisms. Dysregulation or dysfunction of TRPM8 has been associated with various pathologies, such as neuropathic pain, migraine, and some cancers.
The study of TRPM8 holds great promise for understanding the fundamental processes underlying temperature sensation and its implications in therapeutic interventions for temperature-related disorders or sensitivities. Ongoing research and pharmacological development targeting TRPM8 aim to deepen our understanding of its functional mechanisms and explore its potential therapeutic applications in the fields of pain management, sensory disorders, and other temperature-related conditions.
Common Misspellings for TRPM8
- rrpm8
- frpm8
- grpm8
- yrpm8
- 6rpm8
- 5rpm8
- tepm8
- tdpm8
- tfpm8
- ttpm8
- t5pm8
- t4pm8
- trom8
- trlm8
- tr-m8
- tr0m8
- trpn8
- trpk8
- trpj8
- trpm9
- rtrpm8
- trrpm8
- ftrpm8
- tfrpm8
- gtrpm8
- tgrpm8
- ytrpm8
- tyrpm8
- 6trpm8
- t6rpm8
- 5trpm8
- t5rpm8
- terpm8
- trepm8
- tdrpm8
- trdpm8
- trfpm8
- ttrpm8
- trtpm8
- tr5pm8
- t4rpm8
- tr4pm8
- tropm8
- trpom8
- trlpm8
- trplm8
- tr-pm8
- trp-m8
- tr0pm8
- trp0m8
- trpnm8
- trpmn8
- trpkm8
- trpmk8
- trpjm8
- trpmj8
- trpmu8
- trpm8u
- trpmi8
- trpm8i
- trpm98
- trpm89
- rtpm8
- tprm8
- trmp8
- trp8m
- trppm8
- trpmm8
- trpm88
- dRPM8
- pRPM8
- vRPM8
- uRPM8
- TbPM8
- TzPM8
- TvPM8
- TpPM8
- TsPM8
- TRxM8
- TRtM8
- TRrM8
- TRqM8
- TRPe8
- TRPo8
- TRPl8
- TRPMx
- TRPM0
- t rpm8
- trpm 8
Etymology of TRPM8
The term "TRPM8" is an abbreviation for "Transient Receptor Potential cation channel subfamily M member 8". It is derived from the name of the protein that the gene encodes. The "TRP" in TRPM8 refers to "Transient Receptor Potential", which is a family of ion channels that are involved in various sensory and physiological functions. The "M" signifies that it is a member of the subfamily "M", and "8" indicates that it is the 8th member within this subfamily.
Infographic
Add the infographic to your website:
