Weber Christian Disease, also known as nodular nonsuppurative panniculitis or erythema nodosum, is a rare chronic inflammatory condition that affects the subcutaneous fat tissue. It is characterized by the formation of tender nodules or plaques beneath the skin, typically on the legs, arms, buttocks, or trunk.
The exact cause of Weber Christian Disease remains unknown, but it is believed to be an autoimmune disorder. The immune system mistakenly attacks and inflames the fatty tissue, resulting in the formation of nodules. The condition primarily affects adults, with a slightly higher prevalence in women than men.
Symptoms of Weber Christian Disease may include fever, fatigue, weight loss, painful nodules, and skin discoloration. The nodules can vary in size and consistency, ranging from soft to firm. In some cases, the nodules may resolve spontaneously, leaving behind depressed scars.
Diagnosis of Weber Christian Disease involves clinical examination, laboratory tests, and sometimes a skin biopsy. Other conditions that can cause similar symptoms, such as infections or malignancies, must be ruled out.
Treatment for Weber Christian Disease aims to alleviate symptoms and control inflammation. Nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, immunosuppressive medications, and colchicine may be prescribed. In severe cases, surgical removal of the nodules may be considered.
Although Weber Christian Disease is a chronic condition, its course can vary widely among individuals. Some may experience periods of remission, while others may have persistent symptoms. Long-term monitoring and management are crucial to prevent complications and improve quality of life.
